@article{90686,
  keywords = {signal transduction, Vibrio, 4-Butyrolactone, Gene Expression Regulation, Bacterial, Lactones, Homoserine, beta-Galactosidase},
  author = {Kenny Mok and Ned Wingreen and Bonnie Bassler},
  title = {Vibrio harveyi quorum sensing: a coincidence detector for two autoinducers controls gene expression.},
  abstract = { In a process called quorum sensing, bacteria communicate with one another by exchanging chemical signals called autoinducers. In the bioluminescent marine bacterium Vibrio harveyi, two different auto inducers (AI-1 and AI-2) regulate light emission. Detection of and response to the V.harveyi autoinducers are accomplished through two two-component sensory relay systems: AI-1 is detected by the sensor LuxN and AI-2 by LuxPQ. Here we further define the V.harveyi quorum-sensing regulon by identifying 10 new quorum-sensing-controlled target genes. Our examination of signal processing and integration in the V.harveyi quorum-sensing circuit suggests that AI-1 and AI-2 act synergistically, and that the V.harveyi quorum-sensing circuit may function exclusively as a {\textquoteright}coincidence detector{\textquoteright} that discriminates between conditions in which both autoinducers are present and all other conditions. },
  year = {2003},
  journal = {EMBO J},
  volume = {22},
  pages = {870-81},
  month = {02/2003},
  issn = {0261-4189},
  doi = {10.1093/emboj/cdg085},
  language = {eng},
}