@article{90561, keywords = {feedback, Kinetics, algorithms, cells, Biological Evolution, Homeostasis, Cell Growth Processes}, author = {Sidhartha Goyal and Ned Wingreen}, title = {Growth-induced instability in metabolic networks.}, abstract = { Product-feedback inhibition is a ubiquitous regulatory scheme for maintaining homeostasis in living cells. Individual metabolic pathways with product-feedback inhibition are stable as long as one pathway step is rate limiting. However, pathways are often coupled both by the use of a common substrate and by stoichiometric utilization of their products for cell growth. We show that such a coupled network with product-feedback inhibition may exhibit limit-cycle oscillations which arise via a Hopf bifurcation. Our results highlight novel evolutionary constraints on the architecture of metabolism. }, year = {2007}, journal = {Phys Rev Lett}, volume = {98}, pages = {138105}, month = {03/2007}, issn = {0031-9007}, doi = {10.1103/PhysRevLett.98.138105}, language = {eng}, }