@article{90186,
  author = {Gerardo Aquino and Ned Wingreen and Robert Endres},
  title = {Know the Single-Receptor Sensing Limit? Think Again.},
  abstract = { How cells reliably infer information about their environment is a fundamentally important question. While sensing and signaling generally start with cell-surface receptors, the degree of accuracy with which a cell can measure external ligand concentration with even the simplest device-a single receptor-is surprisingly hard to pin down. Recent studies provide conflicting results for the fundamental physical limits. Comparison is made difficult as different studies either suggest different readout mechanisms of the ligand-receptor occupancy, or differ on how ligand diffusion is implemented. Here we critically analyse these studies and present a unifying perspective on the limits of sensing, with wide-ranging biological implications. },
  year = {2016},
  journal = {J Stat Phys},
  volume = {162},
  pages = {1353-1364},
  issn = {0022-4715},
  doi = {10.1007/s10955-015-1412-9},
  language = {eng},
}