@article{200801,
  keywords = {Mutation, *Models, Biological, *Protein Interaction Maps, *Evolution, Molecular},
  author = {M. Z. Ali and N. S. Wingreen and R. Mukhopadhyay},
  title = {Hidden long evolutionary memory in a model biochemical network},
  abstract = { We introduce a minimal model for the evolution of functional protein-interaction networks using a sequence-based mutational algorithm, and apply the model to study neutral drift in networks that yield oscillatory dynamics. Starting with a functional core module, random evolutionary drift increases network complexity even in the absence of specific selective pressures. Surprisingly, we uncover a hidden order in sequence space that gives rise to long-term evolutionary memory, implying strong constraints on network evolution due to the topology of accessible sequence space. },
  year = {2018},
  journal = {Phys Rev E},
  volume = {97},
  number = {4-1},
  pages = {040401},
  month = {04/2018},
  isbn = {2470-0045 (Print)2470-0045},
  language = {eng},
}