@article{200616,
  keywords = {Humans, thermodynamics, Surface Properties, Biomechanical Phenomena, Cell Line, Tumor, Phase Transition, *Models, Chemical, Cell Nucleus/*chemistry, Chromatin/*chemistry},
  author = {Y. Zhang and D. S. W. Lee and Y. Meir and C.P. Brangwynne and N. S. Wingreen},
  title = {Mechanical Frustration of Phase Separation in the Cell Nucleus by Chromatin},
  abstract = { Liquid-liquid phase separation is a fundamental mechanism underlying subcellular organization. Motivated by the striking observation that optogenetically generated droplets in the nucleus display suppressed coarsening dynamics, we study the impact of chromatin mechanics on droplet phase separation. We combine theory and simulation to show that cross-linked chromatin can mechanically suppress droplets{\textquoteright} coalescence and ripening, as well as quantitatively control their number, size, and placement. Our results highlight the role of the subcellular mechanical environment on condensate regulation. },
  year = {2021},
  journal = {Phys Rev Lett},
  volume = {126},
  number = {25},
  pages = {258102},
  month = {06/2021},
  isbn = {0031-9007 (Print)0031-9007},
  language = {eng},
}